For the most up to date list of publications, visit: https://www.ncbi.nlm.nih.gov/myncbi/1zug1rl0RlzQ-/bibliography/public/
Paidi, S.K., Troncoso, J.R., Harper, M.G., Liu, Z, Nguyen, K.G., Ravindranathan, S., Rebello, L., Lee, D.E., Ivers, J.D., Zaharoff, D.A., Rajaram, N., Barman, I. Raman spetroscopy reveals phenotype switches in breast cancer metastases. Theranostics, 12(12): 5351-5363, 2022.
Nguyen, K.G.*, Mantooth, S.M.*, Vrabel, M.R., Zaharoff, D.A. Intranasal delivery of thermostable subunit vaccine for cross-reactive mucosal and systemic antibody responses against SARS-CoV-2. Frontiers of Immunology, 3(3): 858904, 2022.
Nguyen, K.G., Wagner, E.S., Vrabel, M.R., Mantooth, S.M., Meritet, D.M., Zaharoff, D.A. Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders, Bladder Cancer, 7(4):427-37, 2021.
Horton, M., Su, G., Yi, L., Wang, Z., Xu, Y., Pagadala, V., Zhang, F., Zaharoff, D.A., Pearce, K., Linhardt, R.J., Liu, J. Construction of heparan sulfate microarray for investigating the binding of specific saccharide sequences to proteins, Glycobiology, 31(3):188-199, 2021.
Nguyen, K.G., Vrabel, M.R., Mantooth, S.M., Hopkins, J.J., Wagner, E.S., Gabaldon, T.A., Zaharoff, D.A. Localized IL-12 for Cancer Immunotherapy, Frontiers in Immunology, 11:575597, 2020.
Yao,M., Rabbani,Z.N., Sattler, T., Nguyen, K.G., Zaharoff, D.A., Walker, G., Gamcsik, M.P. Flow-encoded oxygen control to track the time-dependence of molecular changes induced by static or cycling hypoxia. Analytical Chemistry, 91(23):15032-15039, 2019.
Kerr, R., Agrawal, S., Maity, S., Koppolu, B., Jayanthi, S., Kumar, G.S. Gundampati, R.K., McNabb, D.S., Zaharoff, D.A., Kumar, T.K.S. Design of a thrombin resistant human acidic fibroblast growth factor (hFGF1) variant that exhibits enhanced cell proliferation activity. Biochem Biophys Res Comm, 518(2): 191-196, 2019.
Fix, S.M., Koppolu, B., Novell, A., Hopkins, J., Kierski, T.M., Zaharoff, D.A., Dayton, P.A., Papadopoulou, V. Ultrasound-Stimulated Phase-Change Contrast Agents for Transepithelial Delivery of Macromolecules, Toward Gastrointestinal Drug Delivery. Ultrasound Med Biol, 45(7):1762-1776, 2019.
Nguyen K.G., Gillam, F.B., Hopkins, J.J., Jayanthi, S., Gundampati, R.K., Su, G., Bear, J., Pilkington, G.R., Jalah, R., Felber, B.K., Liu, J., Thallapuranam, S.K., Zaharoff, D.A. Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity. J Biol Chem, 294(12):4412-4424, 2019
Ravindranathan, S. Nguyen, K.G., Kurtz, S.L., Frazier, H.N., Smith, S.G., Koppolu, B., Rajaram, N., Zaharoff, D.A. Tumor-derived G-CSF diminishes efficacy of breast tumor cell vaccines. Breast Cancer Research, 20(1):126, 2018.
Davis, J.E., Alghanmi, A., Gundampati, R.K., Jayanthi, S., Fields, E., Armstrong, M., Weidling, V., Shah, V., Agrawal, S., Koppolu, B.P., Zaharoff, D.A., Kumar, T.K.S. Probing the role of proline −135 on the structure, stability, and cell proliferation activity of human acidic fibroblast growth factor. Arch Biochem Biophysics, 654: 115-125, 2018.
Smith, S.G., Griffith, B.E., Zaharoff, D.A. Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry. Math Med Biol, 36:139-156, 2019.
Davis, J.E., Gundampati, R.K., Jayanthi, S., Anderson, J., Pickhardt, A., Koppolu, B., Zaharoff, D.A., Kumar, T.K.S. Effect of extension of the heparin binding pocket on the structure, stability, and cell proliferation activity of the human acidic fibroblast growth factor. Biochemistry and Biophysics Reports, 13: 45-57, 2017.
Zaharoff D.A., Jewell, C.M. Strategic Directions in Immunoresponsive Biomaterials in Tissue Engineering. Tissue Engineering Part A, 23(19-20):1042-1043, 2017.
Jayanthi, S., Koppolu, B., Nguyen, K.G., Smith, S.G., Felber, B.K., Kumar, T.K.S., Zaharoff, D.A. Modulation of Interleukin-12 activity in the presence of heparin. Scientific Reports, 7: 5360, 2017. Download
Smith, S.G. Baltz, J.L., Koppolu, B., Ravindranathan, S., Nguyen, K. Zaharoff, D.A. Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer. OncoImmunology, 5(12): e1259050, 2016. Download
Smith, S.G., Zaharoff, D.A. Future Directions in Bladder Cancer Immunotherapy: Towards Adaptive Immunity. Immunotherapy, 8(3):351-65, 2016. Download
Ravindranathan, S., Koppolu, B., Smith, S.G., Zaharoff, D.A. Effect of chitosan properties on immunoreactivity. Marine Drugs, 14(5): 91, 2016. Download
Smith, S.G., Koppolu, B., Ravindranathan, S., Kurtz, S.L., Yang, L., Katz, M.D., Zaharoff, D.A. Intravesical Chitosan/IL-12 Immunotherapy Induces Tumor-Specific Systemic Immunity against Bladder Cancer. Cancer Immunology Immunotherapy, 64(6):689-96, 2015. Download
Vo, J. L., Yang, L., Kurtz, S. L., Smith, S. G., Koppolu, B., Ravindranathan, S., & Zaharoff, D. A. Neoadjuvant immunotherapy with chitosan and interleukin-12 to control breast cancer metastasis. OncoImmunology, 3(12): e968001, 2014. Download
Kurtz, S. L., Ravindranathan, S., & Zaharoff, D. A. Current status of autologous breast tumor cell-based vaccines. Expert review of vaccines, 13(12), 1439-1445, 2014. Download
Jayanthi, S., Koppolu, B., Smith, S. G., Jalah, R., Bear, J., Rosati, M., Pavakis, G.N., Felber, B.K., Zaharoff, D. A. & Kumar, T. K. S. Efficient production and purification of recombinant human interleukin-12 (IL-12) overexpressed in mammalian cells without affinity tag. Protein expression and purification, 102, 76-84, 2014. Download
Koppolu, B., Smith, S. G., Ravindranathan, S., Jayanthi, S., Kumar, T. K. S., & Zaharoff, D. A. Controlling chitosan-based encapsulation for protein and vaccine delivery. Biomaterials, 35(14), 4382-4389, 2014. Download
Kim, J.-W., Galanzha, E.I., Zaharoff, D.A., Griffin, R.J., Zharov, V.I. Nanotheranostics of Circulating Tumor Cells and Other Pathological Cells In Vivo. Molecular Pharmaceutics, 10(3):813-30, 2013. Download
Yang, L., Zaharoff, D.A. Role of chitosan co-formulation in enhancing interleukin-12 delivery and antitumor activity. Biomaterials, 34:3828-36, 2013. Download
Koppolu, B., Zaharoff, D.A. The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells. Biomaterials, 34:2359-69, 2013. Download
Heffernan, M. J., Zaharoff, D. A., Fallon, J. K., Schlom, J., & Greiner, J. W. In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines. Biomaterials, 32(3), 926-932, 2011. Download
Zaharoff, D.A., Hance, K.W., Rogers, C.J., Schlom, J., Greiner, J.W. Intratumoral immunotherapy of established solid tumors with chitosan/IL-12. Journal of Immunotherapy, 33(7):697-705, 2010. Download
Zaharoff, D.A., Hoffman, B.S., Hooper, H.B., Benjamin, C.J., Khurana, K.K., Hance, K.W., Rogers, C.J., Pinto, P.A., Schlom, J., Greiner, J.W. Intravesical immunotherapy of superficial bladder cancer with chitosan/IL-12. Cancer Research, 69(15):6192-9, 2009. Download
Hance, K.W., Rogers, C.J., Zaharoff, D.A., Canter, D., Schlom, J., Greiner, J.W. The antitumor and immunoadjuvant effects of IFN-alpha in combination with recombinant poxvirus vaccines. Clinical Cancer Research, 15(7):2387-96, 2009. Download
Rogers, C.J., Zaharoff, D.A., Hance, K.W., Perkins, S.N., Hursting, S.D., Schlom, J, Greiner, J.W. Exercise enhances vaccine-induced antigen-specific T cell responses. Vaccine, 26(42): 5407-15, 2008.
Zaharoff, D.A., Henshaw, J.W., Mossop, B.J., Yuan, F. Mechanistic analysis of electroporation-induced cellular uptake of macromolecules. Experimental Biology and Medicine, 233(1):94-105, 2008.
Zeytin, H., Reali, E., Zaharoff, D.A., Rogers, C.J., Schlom, J., Greiner, J.W. NK Cell Recruitment to Regional Lymph Nodes and Priming of Tumor-Specific Host Immunity. Journal of Interferon and Cytokine Research, 28(2):73-87, 2008.
Zaharoff, D.A., Rogers, C.J., Hance, K.W., Schlom, J., Greiner, J.W. Chitosan solution enhances the immunoadjuvant properties of GM-CSF. Vaccine, 25(11):8673-8686, 2007.
Rogers, C. J., Berrigan D., Zaharoff, D.A., Hance, K.W., Patel, A.C., Perkins, S.N., Schlom J., Greiner J.W., and Hursting, S.D. Exercise and calorie restriction differentially alter systemic and mucosal immunity. Journal of Nutrition, 138:115-122, 2008.
Zaharoff, D.A., Rogers, C.J., Hance, K.W., Schlom, J., Greiner, J.W. Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination. Vaccine, 25(11):2085-2094, 2007.
Henshaw, J.W., Zaharoff, D.A., Mossop, B.J., Yuan, F. Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo. Bioelectrochemistry, 71(2):233-42, 2007
Mossop, B.J., Barr, R.C., Henshaw, J.W., Zaharoff, D.A., Yuan, F. Electric fields in tumors exposed to external voltage sources: Implication for electric field - mediated drug and gene delivery. Annals of Biomedical Engineering, 34(7):1564-1572, 2006.
McGuire, S.M., Zaharoff, D.A., Yuan, F. Nonlinear dependence of hydraulic conductivity on tissue deformation during intratumoral infusion. Annals of Biomedical Engineering, 34(7):1173-1181, 2006.
Henshaw, J.W., Zaharoff, D.A., Mossop, B.J., Yuan, F. A single molecule detection method for understanding mechanisms of electric-field mediated interstitial transport of genes. Bioelectrochemistry, 69: 248-253, 2006.
Mossop, B.J., Barr, R.C., Zaharoff, D.A., Yuan, F. Electric fields within cells as a function of membrane resistivity – A model study. IEEE Trans. Nanobioscience, 3(3):225-231, 2004.
Zaharoff, D.A., Yuan, F. Effects of pulse strength and pulse duration on in vitro DNA electromobility. Bioelectrochemistry, 62(1):37-45, 2004.
Zhang, L., Widera, G., Bleecher, S., Zaharoff, D.A., Mossop, B., Rabussay, D. Accelerated immune response to DNA vaccines. DNA and Cell Biology, 22(12):815-822, 2003.
Zaharoff, D.A., Barr, R.C., Li, C.Y., Yuan, F. Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. Gene Therapy, 9:1286-1290, 2002.
Lohr, F., Lo, D.Y., Zaharoff, D.A., Hu K., Zhang, X., Li, Y., Zhao, Y., Dewhirst, M.W., Yuan, F., Li, C.-Y. Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation. Cancer Research, 61(8):3281-4, 2001.